Validation of the Predictive Toxicogenomics Space with cell culture data

Pekka Kohonen, Roland Grafström, Egon Willighagen, Juuso Parkkinen, Samuel Kaski & Krister Wennerberg
Cell culture for in vitro cytotoxicity predictions. To validate the predictive performance of the PTGS, a set of CMap instances for 38 compounds that were not included in the NCI-60 data set were assessed. MCF7 (ATCC® HTB22™), PC­3 (ATCC® CRL­1435™) and HL­60 (ATCC® CCL­240™) cell lines were obtained directly from American Type Culture Collection (LGC Promochem AB) and maintained at 37 °C with 5 % CO2 in a humidified incubator according to provider’s instructions. Cell...

1 Related Work

Validation of the Predictive Toxicogenomics Space with cell culture data

Pekka Kohonen, Roland Grafström, Egon Willighagen, Juuso Parkkinen, Samuel Kaski & Krister Wennerberg
Cell culture for in vitro cytotoxicity predictions. To validate the predictive performance of the PTGS, a set of CMap instances for 38 compounds that were not included in the NCI-60 data set were assessed. MCF7 (ATCC® HTB22™), PC­3 (ATCC® CRL­1435™) and HL­60 (ATCC® CCL­240™) cell lines were obtained directly from American Type Culture Collection (LGC Promochem AB) and maintained at 37 °C with 5 % CO2 in a humidified incubator according to provider’s instructions. Cell...

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