Redox-triggered mitoxantrone prodrug micelles for overcoming multidrug-resistant breast cancer

Hongzhi Qiao, Zhenzhu Zhu, Dong Fang, Yuan Sun, Chen Kang, Liuqing Di, Lei Zhang & Yahan Gao
Multidrug resistance (MDR) severely hinders the efficient chemotherapeutic treatments of cancer. d-α-Tocopherol polyethylene 1000 succinate (TPGS) based drug delivery system holds the potential of re-sensitizing resistant cancer cells. In this study, a TPGS prodrug containing both TPGS and mitoxantrone (MTO) via a disulphide bond was synthesised and assembled into micelle (TSMm) with a monodispersed diameter of 46.50 ± 1.12 nm. The disulphide bonds within the micelles could be cleaved in response to a high concentration...
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