Supplementary Material for: Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

A. Cajanus, A. Hall, J. Koikkalainen, E. Solje, A. Tolonen, T. Urhemaa, Y. Liu, R.M. Haanpää, P. Hartikainen, S. Helisalmi, V. Korhonen, D. Rueckert, S. Hasselbalch, G. Waldemar, P. Mecocci, R. Vanninen, M. Van Gils, H. Soininen, J. Lötjönen & A.M. Remes
Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72-related genetic status in the differentiation sensitivity. Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold...
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