Changes in extracellular matrix in subcutaneous small resistance arteries of patients with essential hypertension

Gaia Favero, Anna Paini, Carolina De Ciuceis, Luigi F. Rodella, Enrico Moretti, Enzo Porteri, Claudia Rossini, Silvia Ministrini, Leonardo Solaini, Caletti Stefano, Maria Antonietta Coschignano, Valeria Brami, Alina Petelca, Matteo Nardin, Ilenia Valli, Guido A. M. Tiberio, Francesca Bonomini, Claudia Agabiti Rosei, Nazario Portolani, Damiano Rizzoni & Rita Rezzani
Background: In the development of hypertensive microvascular remodeling, a relevant role may be played by changes in extracellular matrix proteins. Aim of this study was the to evaluate some extracellular matrix components within the tunica media of subcutaneous small arteries in 9 normotensive subjects and 12 essential hypertensive patients, submitted to a biopsy of subcutaneous fat from the gluteal or the anterior abdominal region. Patients and Methods: Subcutaneous small resistance arteries were dissected and mounted...
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