Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1 H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydro-imidazo[1,2-a]quinolines

Xian-Yu Sun, Mei-Yu Liu, Chun-Yan Zhong, Gui-Lin Zheng, Ming-Yue Lv, Bo-Tao Jing, Chun-Yuan Pan & Xin Wang
A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gram-negative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4-256 nmol mL-1 in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL-1, smaller than...
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