Liquid Handling Processes Impact Computational Modeling in Drug Discovery

Antony Williams
The introduction of new pharmaceutical drugs has slowed while money and effort expended by the industry has dramatically increased. We suggest that some of that effort may be inadvertently wasted in drug screening and quantitative structure-activity relationship studies where results can be strongly skewed by the method of liquid handling and the protocol used. Recent work has demonstrated that dispensing processes have a profound influence on estimates of IC50. What appear to be minor modifications...
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