Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy

, , , , Bin Huang, , Di Zhang, , Qing Zhang, Zheng Jiang, Rolf Bjerkvig, Lars Prestegarden, Frits Thorsen, , & Jian Wang
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism of action, however, remains unclear. Here, we evaluated the efficacy of FKB in the treatment of human glioblastoma multiforme (GBM) as well as the molecular basis for its inhibitory effects in cancer. Approximately 60% of GBM cells became senescent after treatment with FKB as assessed in the senescence-associated (SA)-GLB1/SA-β-galactosidase assay. The cellular process of autophagy potentially contributed...
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