Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activation

Li Wang, Xinyuan Qiao, Sijia Zhang, Yue Qin, Tiantian Guo, Zhenye Hao, Li Sun, Xiaona Wang, Yanan Wang, Yanping Jiang, Lijie Tang, Yigang Xu & Yijing Li
Transmissible gastroenteritis virus (TGEV) infection causes acute enteritis in swine of all ages, and especially in suckling piglets. Small intestinal inflammation is considered a central event in the pathogenesis of TGEV infections, and nuclear factor-kappa B (NF-κB) is a key transcription factor in the inflammatory response. However, it is unclear whether NF-κB is crucial for inducing inflammation during a TGEV infection. Our results show that NF-κB was activated in swine testicular (ST) cells and intestinal...
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