The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses

Peixi Chang, Weitian Li, Guolin Shi, Huan Li, Xiaoqing Yang, Zechen Xia, Yuan Ren, Zhiwei Li, Huanchun Chen & Weicheng Bei
Streptococcus suis is a highly invasive pathogen that can cause sepsis and meningitis in pigs and humans. However, we have limited understanding of the mechanisms S. suis uses to evade innate immunity. To investigate the involvement of the two-component signal transduction system of S. suis in host immune defense, we examined the expression of 15 response regulators of S. suis following stimulation with polymorphonuclear leukocytes (PMNs). We found that several response regulators were significantly up-regulated...
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