Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells

Zeinab Al-Rekabi, Adriane M. Fura, Ilsa Juhlin, Alaa Yassin, Tracy E. Popowics & Nathan J. Sniadecki
The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. While HA-CD44 interactions have previously been implicated in numerous cell types; effect and mechanism of exogenous HA on periodontal ligament (PDL) cells is less clear. Herein, we examine the effect of exogenous HA on contractility and migration in human and murine PDL cells using arrays of microposts and time-lapse microscopy. Our findings observed HA-treated human PDL cells...
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