Evaluation of an in vitro coronary stent thrombosis model for preclinical assessment

Dylan Perry-Nguyen, Richard G. Jung, Alisha Labinaz, Anne-Claire Duchez, Omar Dewidar, Trevor Simard, Denuja Karunakaran, Kamran Majeed, Kiran Sarathy, Ruonan Li, F. Daniel Ramirez, Pietro Di Santo, Rebecca Rochman, Derek So, Nicolas Foin & Benjamin Hibbert
Stent thrombosis remains an infrequent but significant complication following percutaneous coronary intervention. Preclinical models to rapidly screen and validate therapeutic compounds for efficacy are lacking. Herein, we describe a reproducible, high throughput and cost-effective method to evaluate candidate therapeutics and devices for either treatment or propensity to develop stent thrombosis in an in vitro bench-top model. Increasing degree of stent malapposition (0.00 mm, 0.10 mm, 0.25 mm and 0.50 mm) was associated with increasing thrombosis...
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