Application of high-sensitivity flow cytometry in combination with low-voltage scanning electron microscopy for characterization of nanosized objects during platelet concentrate storage

Anton Fedorov, Kirill Kondratov, Vasilii Kishenko, Vladimir Mikhailovskii, Igor Kudryavtsev, Margarita Belyakova, Sergey Sidorkevich, Tatyana Vavilova, Anna Kostareva, Olga Sirotkina & Alexey Golovkin
Platelet concentrates are used in clinic for therapy and prophylaxis of conditions associated with platelet deficiency or malfunction. The characteristics of platelet concentrates gradually change during pretransfusion storage, affecting their clinical effectiveness and the risk of adverse transfusion reactions. The presence of platelet-derived membrane vesicles is an important characteristic of platelet concentrates. Due to their functionality, changes in the number and molecular compositions of platelet-derived vesicles have major effects on the clinical properties of platelet...
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