The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C Clement, Cara A Reynolds, Bindi Patel, Laura Santambrogio, Ana M Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...
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