The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...
This data center is not currently reporting usage information. For information on how your repository can submit usage information, please see our Documentation.