A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

Yanan Wang, Tianyu Han, Mingxi Gan, Meng Guo, Caifeng Xie, Jiangbo Jin, Song Zhang, Pengcheng Wang, Jiaqing Cao & Jian-Bin Wang
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of...
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