The in vitro effect of antirheumatic drugs on platelet function

Camilla Brødsgaard Nielsen, Christian Nielsen, Mads Nybo, Søren Andreas Just & Pernille Just Vinholt
Several antirheumatic drugs lower the cardiovascular risk among rheumatoid arthritis patients. It is, however, unknown whether inhibition of platelet function contributes to this risk reduction. Only few studies have investigated the potential role of platelets as a target of antirheumatic drugs. In this study, platelet function was tested in vitro in samples from 24 healthy individuals spiked with antirheumatic drugs in clinically relevant concentrations or vehicle. Platelet aggregation was tested with 96-well light transmission aggregometry...
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