Determination of two drugs of abuse in saliva has been performed by Paper Spray Ionization Mass Spectrometry (PSI-MS) using a Molecularly Imprinted Polymer (MIP) coated paper as substrate. The method has been optimized for quantification of 3,4-methylenedioxy- N-methylamphetamine (MDMA) and methamphetamine, 3,4-methylenedioxyamphetamine (MDA) from synthetic saliva samples. Rapid analysis (~ 1 min) of designer drugs in saliva is demonstrated using MIP-PSI-MS. Both precursor ions of MDMA and MDA were confirmed by tandem mass spectrometry (MS/MS)...
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