ARE THE INTRAEPIDERMAL HIGH-GRADE MELANOCYTIC LESIONS THE DIRECT PRECURSORS OF INVASIVE MALIGNANT MELANOMAS?

Salvador J. Diaz-Cano, , , , &
Introduction: No topographic evaluation on cell kinetic and cell cycle regulators is available for atypical melanocytic nevi (AMN) and melanomas in situ (MIS).
Methods: We selected AMN (92 low-grade, 31 high-grade), MIS (10), malignant melanomas (MM, 15 radial growth phase and 27 vertical growth phase), and melanocytic nevi (15 junctional, 20 compound). Junctional and dermal (above and below 0.76mm) immunostainings for Ki-67, p53, p21 WAF1 , and p27Kip1 and in situ end labeling (ISEL) for apoptosis...
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