GENETIC HETEROGENEITY BY TOPOGRAPHIC COMPARTMENTS IN PHEOCHROMOCYTOMAS SUGGEST A CONVERGENT CELL SELECTION IN THE PERIPHERAL AREA

Salvador J. Diaz-Cano, , , , &
Background: Adrenal pheochromocytomas have been extensively studied at the molecular level, but no information is available on their molecular profile by topographic compartments
Methods: Microdissected samples from the peripheral and internal zones of 73 pheochromocytomas (49 sporadic, 24 associated to MEN2A) were selected for loss of heterozygosity (LOH) and single nucleotide polymorphism (SNP) analyses. Five polymorphic DNA regions from TP53, RB1, WT1, and NF1 were systematically studied by polymerase chain reaction-denaturing gradient gel electrophoresis. Statistical differences...
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