HIGH PROLIFERATION AND NORMAL APOPTOSIS ARE THE KINETIC HALLMARKS OF CUTANEOUS MERKEL CELL CARCINOMAS

Salvador J. Diaz-Cano, , , , , &
Background: Merkel cell carcinomas (MCCs) are unusual cutaneous neoplasms that reveal both epithelial and neuroendocrine differentiation. No detailed analysis of cell kinetics (proliferation and apoptosis) by topographic compartments is available to date. Methods: All MCCs were required to express at least two epithelial and two neural markers from a panel including cytokeratin cocktail AEl -AE3, cytokeratin 20, synaptophysin, chromogranin A, neurofilament protein, and neuron-specific enolase, along with consistent ultrastructural findings. We selected 19 MCCs to...
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