Poor Prognosis and a Distinctive Genetic Profile Define Muscle- Invasive Transitional Cell Carcinoma of the Bladder with Single-File Infiltration Pattern

Salvador J. Diaz-Cano, , , , &
Background: Histologic patterns have been demonstrated prognostically useful in transitional cell carcinomas (TCC) of the bladder, especially for the distinction between superficial and invasive neoplasms. No information is available on the prognostic significance and genetic profile of invasive patterns in muscle-invasive TCC.
Methods: Seventy-twomuscle-invasiveTCC of the bladder were histologically evaluated regarding a pondered histologic grade (low vs. high), and MIB-1 index. The infiltrationpattern was assessed in the deep compartment and classified according to the predominant pattern...
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