Clonal and Kinetic Profiles Correlate with Vascular Patterns in Adrenal Cortical Lesions

Salvador J. Diaz-Cano, , , &
Background: Monoclonal adrenal cortical lesions have been characterized by an inverse correlation between proliferation and apoptosis, while polyclonal lesions reveal a direct correlation. Their relationship with the vascular pattern remains unknown in nodular hyperplasias (ACNH), adenomas (ACA), and carcinomas (ACC) of the adrenal cortex.
Methods: We studied 20 ACNH, 25 ACA, and 10 ACC, classified according to WHO's criteria, from 55 females. Representative samples were histologically evaluated and microdissected to study clonality by X-chromosome inactivation. Proliferation...
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