Concordant Inactivated X-Chromosome Results from Early Monoclonal Expansions of Neural Crest Precursors in MEN-2A

Salvador J. Diaz-Cano, , , &
Background: The histologic definition of precursor lesions in MEN is controversial for both C-Cell Hyperplasia (CCH) and Adrenal Medullary Hyperplasia (AMH). They are multifocal and the clonality pattern of each focus remains unknown.
Methods: We found 10 females with bilateral CCH and another 11 with AMH in a MEN-2A kindred known to carry RET point mutation in codon 634. DNA was extracted from microdissected samples of CCH from each thyroid lobe and from 34 AMH nodules...
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