Additional file 1: of Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice

Alba Llop-Guevara, Mónica Porras, Carla Cendón, Irene Di Ceglie, Francesco Siracusa, Federica Madarena, , , Peter Van Lent, Eleni Douni, Hyun Dong Chang, Thomas Kamradt & Juan Román
Potency, selectivity and pharmacokinetics of tofacitinib/CP-690,550 (Janus kinase inhibitor ( JAKi )) and PRT-062607 (spleen tyrosine kinase inhibitor ( SYKi )). a, b Human cell lines were pre-incubated with increasing concentrations of JAKi or SYKi (0.005 to 5 μM) for 1 h and then stimulated with either 100 ng/ml rmIL-6 for 15 minutes or 10 μg/ml anti-IgM for 5 minutes. Cells were fixed, permeabilized, stained with anti-STAT3(pY705)-Alexa Fluor 647 or anti-BLNK(pY84)-Alexa Fluor 488 and quantified...
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