Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis

Katerina Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios Koutsopoulos, Eleni Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos Siafakas, Nikolaos Tzanakis, Athol Wells & Katerina Antoniou
Abstract Background Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity. Approximately, 10% of RA patients develop clinically significantly ILD. A possible shared role of protein citrullination in rheumatoid arthritis associated interstitial lung disease (RA-ILD), and idiopathic pulmonary fibrosis (IPF) pathogenesis remains unclear. Methods We evaluated PADI2 and PADI4 mRNA expression in bronchoalveolar lavage fluid (BALF) cells...
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