Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo

Robert Verity, Nicholas Hathaway, Andreea Waltmann, Stephanie Doctor, Oliver Watson, Jaymin Patel, Kashamuka Mwandagalirwa, Antoinette Tshefu, Jeffrey Bailey, Azra Ghani, Jonathan Juliano & Steven Meshnick
Abstract Background The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiology of PAM, and in developing a robust vaccine against PAM. Methods Samples were taken from the 2013â 14 Demographic and Health Survey conducted in the...
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