Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo

Robert Verity, Nicholas Hathaway, Andreea Waltmann, Stephanie Doctor, Oliver Watson, , , Antoinette Tshefu, Jeffrey Bailey, Azra Ghani, Jonathan Juliano & Steven Meshnick
Abstract Background The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiology of PAM, and in developing a robust vaccine against PAM. Methods Samples were taken from the 2013â 14 Demographic and Health Survey conducted in the...
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