Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming

Srijaya Thekkeparambil Chandrabose, Sandhya Sriram, Subha Subramanian, Shanshan Cheng, Wee Ong, Steve Rozen, Noor Kasim & Shigeki Sugii
Abstract Background While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sources and protocols for efficient reprogramming. Methods Here, we show a robust episomal and xeno-free reprogramming strategy for human iPS generation from dental pulp stem cells (DPSCs) which renders good efficiency (0.19%) over a short time frame (13â 18 days). Results The robustness...
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