YM155 decreases radiation-induced invasion and reverses epithelialâ mesenchymal transition by targeting STAT3 in glioblastoma

Xin Zhang, , Ran Xu, , , , , Bin Huang, , Qing Zhang, , Jian Wang, & Chen Qiu
Abstract Background Radiotherapy constitutes a standard arm of therapy in the multimodal treatment of patients with glioblastoma (GBM). Ironically, studies have recently revealed that radiation can augment malignant progression, by promoting migration and invasion, which make the disease especially difficult to cure. Here, we investigated the anticancer effects of YM155, a purported radiosensitizer, in GBM cell lines. Methods GBM cell lines U251 and U87 were treated with YM155 to assess cytotoxicity and activity of the...
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