Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study

Julie Wright, Kyla Hayford, Vanessa Tran, Gulam Al Kibria, Abdullah Baqui, Ali Manajjir, Arif Mahmud, , , Kevin Kain &
Abstract Background Reducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome. Methods We conducted a matched case-control (1:3) study of 98 young infants aged 0–59 days of life presenting to a referral hospital in Bangladesh with suspected...
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