Supplementary material from \"Interplay of self-association and conformational flexibility in regulating protein function\"

Michael Garton, Stephen S. MacKinnon, Anatoly Malevanets & Shoshana J. Wodak
Many functional roles have been attributed to homodimers, the most common mode of protein self-association, notably in the regulation of enzymes, ion channels, transporters and transcription factors. Here we review findings that offer new insights into the different roles conformational flexibility plays in regulating homodimer function. Intertwined homodimers of two-domain proteins and their related family members, display significant conformational flexibility, which translates into concerted motion between structural domains. This flexibility enables the corresponding proteins to...
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