Supplementary material from \"Folding cooperativity and allosteric function in the tandem-repeat protein class\"

Albert Perez-Riba, Marie Synakewicz & Laura S. Itzhaki
The term allostery was originally developed to describe structural changes in one binding site induced by the interaction of a partner molecule with a distant binding site, and it has been studied in depth in the field of enzymology. Here, we discuss the concept of action at a distance in relation to the folding and function of the solenoid class of tandem-repeat proteins such as tetratricopeptide repeats (TPRs) and ankyrin repeats. Distantly located repeats fold...
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