Supplementary material from "Axon growth regulation by a bistable molecular switch"

Pranesh Padmanabhan & Geoffrey J. Goodhill
For the brain to function properly, its neurons must make the right connections during neural development. A key aspect of this process is the tight regulation of axon growth as axons navigate towards their targets. Neuronal growth cones at the tips of developing axons switch between growth and paused states during axonal pathfinding, and this switching behaviour critically determines the heterogeneous axon growth rates observed during brain development. The mechanisms controlling this switching behaviour, however,...
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