Engineering of E. coli inherent fatty acid biosynthesis capacity to increase octanoic acid production

Zaigao Tan, Jong Yoon, Anupam Chowdhury, Kaitlin Burdick, Laura Jarboe, Costas Maranas & Jacqueline Shanks
Abstract Background As a versatile platform chemical, construction of microbial catalysts for free octanoic acid production from biorenewable feedstocks is a promising alternative to existing petroleum-based methods. However, the bio-production strategy has been restricted by the low capacity of E. coli inherent fatty acid biosynthesis. In this study, a combination of integrated computational and experimental approach was performed to manipulate the E. coli existing metabolic network, with the objective of improving bio-octanoic acid production. Results...
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