Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition

Sun Kyung, Dae Kim, Jin Yoon, Eun Son, Yu Kim, Jeong Park & Sung Jeong
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective treatment. The epithelial-mesenchymal transition (EMT) is a critical stage during the development of fibrosis. To assess the effect of sulforaphane (SFN) on the EMT and fibrosis using an in vitro transforming growth factor (TGF)-β1-induced model and an in vivo bleomycin (BLM)-induced model. Methods In vitro studies, cell viability, and cytotoxicity were measured using a Cell Counting Kit-8. The functional TGF-β1-induced...
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