Online immunocapture ICP-MS for the determination of the metalloprotein ceruloplasmin in human serum

Bogdan Bernevic, Ahmed El-Khatib, Norbert Jakubowski & Michael Weller
Abstract Objective The human copper-protein ceruloplasmin (Cp) is the major copper-containing protein in the human body. The accurate determination of Cp is mandatory for the reliable diagnosis of several diseases. However, the analysis of Cp has proven to be difficult. The aim of our work was a proof of concept for the determination of a metalloprotein-based on online immunocapture ICP-MS. The immuno-affinity step is responsible for the enrichment and isolation of the analyte from serum,...
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