Carbon nanomaterial-derived lung burden analysis using UV-Vis spectrophotometry and proteinase K digestion

Dong-Keun Lee, , , Kyung Seuk Song & Wan-Seob Cho
Abstract Background The quantification of nanomaterials accumulated in various organs is crucial in studying their toxicity and toxicokinetics. However, some types of nanomaterials, including carbon nanomaterials (CNMs), are difficult to quantify in a biological matrix. Therefore, developing improved methodologies for quantification of CNMs in vital organs is instrumental in their continued modification and application. Results In this study, carbon black, nanodiamond, multi-walled carbon nanotube, carbon nanofiber, and graphene nanoplatelet were assembled and used as a...
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