β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

, , , Peng Zheng, Peng Zhang, , Qiao Wang, Wei Pan, , Tao Hu, , , Feng Zhou, & Xu-Feng Huang
Abstract Background “Western” style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low in fiber. This diet pattern is associated with a myriad of metabolic dysfunctions, including neuroinflammation and cognitive impairment. β-glucan, the major soluble fiber in oat and barley grains, is fermented in the lower gastrointestinal tract, potentially impacting the microbial ecosystem and thus may improve elements of cognition and brain function via the gut-brain axis....
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