Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway

Kaitlin C. Fogg, Andrew E. Miller, Ying Li, Will Flanigan, Alyssa Walker, Andrea O’Shea, Christina Kendziorski & Pamela K. Kreeger
Abstract Background Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels of AAMs are correlated with poor HGSOC survival rates, and AAMs increase the attachment and spread of HGSOC cells in vitro. However, the mechanism by which monocytes in the HGSOC tumor microenvironment are differentiated and polarized to AAMs remains unknown. Methods Using an in vitro co-culture device, we cultured naïve, primary...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.