Hepatitis B virus promotes hepatocellular carcinoma development by activating GP73 to repress the innate immune response

Long Liu, Yanping Huang, Yanan Fu, Jingjing Rao, Feng Zeng, Manshan Ji, Xiang Xu, Jianyong Zhu, Weixing Du & Zhixin Liu
Abstract Background Hepatitis B virus (HBV) causes acute and chronic infection in the clinic. Hepatocellular carcinoma (HCC) is closely linked to HBV infection. Serum Golgi protein 73 (GP73) increases during HBV infection. However, the role of GP73 during HBV infection and the occurrence of HBV-related HCC is still poorly understood. Methods The underlying role of HBV-induced GP73 in regulating HCC development was investigated in this study. GP73 expression in HBV-related clinical HCC tissues and in...
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