Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen & Paul M. Matthews
Abstract Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulating body of research indicates that microglia may play a causal role in the pathogenesis of this disease. We hypothesised that sex differences in the transcriptome of human myeloid cells may contribute to the sex difference observed in AD prevalence. To explore this, we assessed bulk and single-nuclear...
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