Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Dan Lv, Yangpan Ou, Yunhui Chen, Zhenning Ding, Jidong Ma, Chuang Zhan, Ru Yang, Tinghuizi Shang, Guangfeng Zhang, Xiaoyu Bai, Zhenghai Sun, Jian Xiao, Xiaoping Wang, Wenbin Guo & Ping Li
Abstract Background Brain functional abnormalities at rest have been observed in obsessive–compulsive disorder (OCD). However, whether and how anatomical distance influences functional connectivity (FC) at rest is ambiguous in OCD. Methods Using resting-state functional magnetic resonance imaging data, we calculated the FC of each voxel in the whole-brain and divided FC into short- and long-range FCs in 40 medicine-free patients with OCD and 40 healthy controls (HCs). A support vector machine (SVM) was used to...
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