Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes

Manuel Sanchez, Caroline Kannengiesser, Sophie Hoang, Louis Potier, Frédéric Fumeron, Nicolas Venteclef, André Scheen, Jean-François Gautier, Samy Hadjadj, Michel Marre, Ronan Roussel, Kamel Mohammedi & Gilberto Velho
Abstract Background Type 1 diabetes is associated with accelerated vascular aging and advanced atherosclerosis resulting in increased rates of cardiovascular disease and premature death. We evaluated associations between Leukocyte telomere length (LTL), allelic variations (SNPs) in LTL-related genes and the incidence of coronary heart disease (CHD) in adults with long-standing type 1 diabetes. Methods We assessed associations of LTL, measured at baseline by RT–PCR, and of SNPs in 11 LTL-related genes with the risk of...
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