Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian & Jian Xiao
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary gastrointestinal-DLBCL (pGI-DLBCL) harbors different genetic mutations from other nodal or extranodal DLBCL. However, the exonic mutation profile of pGI-DLBCL has not been fully addressed. Methods We performed whole-exome sequencing of matched tumor tissues and blood samples from 53 pGI-DLBCL patients. The exonic mutation...
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