MiR-493-5p inhibits Th9 cell differentiation in allergic asthma by targeting FOXO1

Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu & Zhengrong Chen
Abstract The role of micro RNAs (miRNAs) in asthma remains unclear. In this study, we examined the role of miRNA in targeting FOXO1 in asthma. Results showed that miR-493-5p was one of the differentially expressed miRNAs in the PBMCs of asthmatic children, and was also associated with Th cell differentiation. The miR-493-5p expression decreased significantly in the OVA-induced asthma mice than the control groups. The miR-493-5p mimic inhibited the expression of the IL-9, IRF4 and...
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