Integrated assessment of the clinical and biological value of ferroptosis-related genes in multiple myeloma

Bibo Fu, Ruonan Shao, Huizhong Wang, Guanjun Chen, Shenrui Bai & Hua Wang
Abstract Background Ferroptosis is an iron-dependent mode of cell death that could be induced by erastin and exert antitumor effects. However, the clinical and biological roles of ferroptosis-related gene (FRG) signature and the therapeutic value of erastin in multiple myeloma (MM) remained unknown. Methods Clinical and gene expression data of MM subjects were extracted from the Gene Expression Omnibus (GEO) public database. Univariable cox analysis was applied to determine FRGs related to survival and the...
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