An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl & Lukas Schwingshackl
Abstract Background Randomized controlled trials (RCTs) and cohort studies are the most common study design types used to assess treatment effects of medical interventions. We aimed to hypothetically pool bodies of evidence (BoE) from RCTs with matched BoE from cohort studies included in the same systematic review. Methods BoE derived from systematic reviews of RCTs and cohort studies published in the 13 medical journals with the highest impact factor were considered. We re-analyzed effect estimates...
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