High-definition transcranial direct current stimulation (HD-tDCS) as augmentation therapy in late-life depression (LLD) with suboptimal response to treatment—a study protocol for a double-blinded randomized sham-controlled trial

Sze Ting Joanna Ngan, Lap Kei Chan, Wai Chi Chan, Linda Chiu Wa Lam, Wan Kei Li, Kelvin Lim, Ego Or, Pui Fai Pang, Ting Keung Poon, Mei Cheung Mimi Wong, Ying King Anna Wu & Pak Wing Calvin Cheng
Abstract Background Late-life depression (LLD) has a poorer prognosis and higher relapse rate than younger adults, with up to one third of patients with LLD showing suboptimal response to antidepressant therapy. LLD has been associated with significant impairment in cognition and daily functioning. Few studies have evaluated the therapeutic effects of high-definition transcranial direct current stimulation (HD-tDCS) on depressive and cognitive symptoms of LLD. The current randomized controlled trial assesses the efficacy of HD-tDCS as...
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