A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

Yasmine Sommerer, Olena Ohlei, Valerija Dobricic, Derek H. Oakley, Tanja Wesse, Sanaz Sedghpour Sabet, Ilja Demuth, Andre Franke, Bradley T. Hyman, Christina M. Lill & Lars Bertram
Abstract Epigenome-wide association studies (EWAS) assessing the link between DNA methylation (DNAm) and phenotypes related to structural brain measures, cognitive function, and neurodegenerative diseases are becoming increasingly more popular. Due to the inaccessibility of brain tissue in humans, several studies use peripheral tissues such as blood, buccal swabs, and saliva as surrogates. To aid the functional interpretation of EWAS findings in such settings, there is a need to assess the correlation of DNAm variability across...
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