Defects of microtubule cytoskeletal organization in NOA human testes

Xiaolong Wu, Damin Yun, Mengmeng Sang, Jianpeng Liu, Liwei Zhou, Jie Shi, Lingling Wang, Tiao Bu, Linxi Li, YingYing Huang, Dengfeng Lin, Fei Sun & C. Yan Cheng
Abstract The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is known to some extent, but its role in the etiology of azoospermia in humans remains unexplored. Here, we examined if MT cytoskeleton was defective in NOA (non-obstructive azoospermia) testes versus normal human testes based on histopathological, immunofluorescence (IF), and scRNA-Seq transcriptome profiling. Testis biopsy samples from n = 6 normal men versus n = 3 Sertoli cell only (SCO) and...
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