Automated classification of protein expression levels in immunohistochemistry images to improve the detection of cancer biomarkers

Zhen-Zhen Xue, Cheng Li, Zhuo-Ming Luo, Shan-Shan Wang & Ying-Ying Xu
Abstract Background The expression changes of some proteins are associated with cancer progression, and can be used as biomarkers in cancer diagnosis. Automated systems have been frequently applied in the large-scale detection of protein biomarkers and have provided a valuable complement for wet-laboratory experiments. For example, our previous work used an immunohistochemical image-based machine learning classifier of protein subcellular locations to screen biomarker proteins that change locations in colon cancer tissues. The tool could recognize...
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